منابع مشابه
A possible physiological role of Abeta as a crosslinker
Although soluble oligomers are regarded as the most toxic aggregates of Abeta, the amyloidogenic nature of Abeta certainly is not accidental and should play a role in the still unknown physiological functions of Abeta. The testable hypothesis put forward here postulates that short Abeta oligomers can crosslink the neurotrophin receptor p75 with APP and other proteins and mediate a direct cooper...
متن کاملA bisazobenzene crosslinker that isomerizes with visible light
BACKGROUND Large conformational and functional changes of azobenzene-modified biomolecules require longer azobenzene derivatives that undergo large end-to-end distance changes upon photoisomerization. In addition, isomerization that occurs with visible rather than UV irradiation is preferred for biological applications. RESULTS We report the synthesis and characterization of a new crosslinker...
متن کاملMechanical Properties of DNA-Crosslinked Polyacrylamide Hydrogels with Increasing Crosslinker Density
DNA-cross-linked polyacrylamide hydrogels (DNA gels) are dynamic mechanical substrates. The addition of DNA oligomers can either increase or decrease the crosslinker density to modulate mechanical properties. These DNA-responsive gels show promise as substrates for cell culture and tissue-engineering applications, since the gels allow time-dependent mechanical modulation. Previously, we reporte...
متن کاملNovel actin crosslinker superfamily member identified by a two step degenerate PCR procedure.
Actin-crosslinking proteins link F-actin into the bundles and networks that constitute the cytoskeleton. Dystrophin, beta-spectrin, alpha-actinin, ABP-120, ABP-280, and fimbrin share homologous actin-binding domains and comprise an actin crosslinker superfamily. We have identified a novel member of this superfamily (ACF7) using a degenerate primer-mediated PCR strategy that was optimized to res...
متن کاملEnriching carbonylated proteins inside a microchip through the use of oxalyldihydrazide as a crosslinker.
We report a proof of principle study for the use of oxalyldihydrazide as a crosslinker for enrichment of carbonylated proteins within a microfluidic chip. Surface modification steps are characterized and analyzed using analytical techniques. We use oxidized cytochrome c as our model protein and demonstrate the chip's ability to capture carbonylated targets. After 100 min of continuous loading, ...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 2015
ISSN: 0913-5006,1881-2732
DOI: 10.2745/dds.30.247